2020 |
Cianflone, E; Cappetta, D; Mancuso, T; Sabatino, J; Marino, F; Scalise, M; Albanese, M; Salatino, A; Parrotta, EI; Cuda, G; DeAngelis, A; Berrino, L; Rossi, F; Nadal-Ginard, B; Torella, D; Urbanek, K International Journal of Molecular Sciences, 21 (7927), 2020. @article{cianfly_2020b, title = {Statins Stimulate New Myocyte Formation After Myocardial Infarction by Activating Growth and Differentiation of the Endogenous Cardiac Stem Cells}, author = {E Cianflone and D Cappetta and T Mancuso and J Sabatino and F Marino and M Scalise and M Albanese and A Salatino and EI Parrotta and G Cuda and A DeAngelis and L Berrino and F Rossi and B Nadal-Ginard and D Torella and K Urbanek}, editor = {Multidisciplinary Digital Publishing Institute}, url = {https://www.mdpi.com/1422-0067/21/21/7927}, doi = {https://doi.org/10.3390/ijms21217927}, year = {2020}, date = {2020-10-26}, journal = {International Journal of Molecular Sciences}, volume = {21}, number = {7927}, keywords = {2020}, pubstate = {published}, tppubtype = {article} } |
Cianflone, E; Torella, M; Biamonte, F; DeAngelis, A; Urbanek, K; Costanzo, FS; Rota, M; Hellison-Hughes, GM; Torella, D Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease Journal Article Cells, 9 (6), pp. 1558, 2020. @article{cianflone_2020, title = {Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease}, author = {E Cianflone and M Torella and F Biamonte and A DeAngelis and K Urbanek and FS Costanzo and M Rota and GM Hellison-Hughes and D Torella}, editor = {Multidisciplinary Digital Publishing Institute}, url = {https://www.mdpi.com/2073-4409/9/6/1558}, doi = {https://doi.org/10.3390/cells9061558}, year = {2020}, date = {2020-06-26}, journal = {Cells}, volume = {9}, number = {6}, pages = {1558}, keywords = {2020}, pubstate = {published}, tppubtype = {article} } |
Mancuso, T; Barone, A; Salatino, A; Molinaro, C; Marino, F; Scalise, M; Torella, M; DeAngelis, A; Urbanek, K; Torella, D; Cianflone, E Unravelling the Biology of Adult Cardiac Stem Cell-Derived Exosomes to Foster Endogenous Cardiac Regeneration and Repair Journal Article Int. J. Mol. Sci., 21 (10), pp. 3725, 2020. @article{mancuso2020, title = {Unravelling the Biology of Adult Cardiac Stem Cell-Derived Exosomes to Foster Endogenous Cardiac Regeneration and Repair}, author = {T Mancuso and A Barone and A Salatino and C Molinaro and F Marino and M Scalise and M Torella and A DeAngelis and K Urbanek and D Torella and E Cianflone}, url = {https://doi.org/10.3390/ijms21103725}, doi = {10.3390/ijms21103725}, year = {2020}, date = {2020-05-25}, journal = {Int. J. Mol. Sci.}, volume = {21}, number = {10}, pages = {3725}, keywords = {2020}, pubstate = {published}, tppubtype = {article} } |
Scalise, M; Torella, M; Marino, F; Ravo, M; Giurato, G; Vicinanza, C; Cianflone, E; Mancuso, T; Aquila, I; Salerno, L; Nassa, G; Agosti, V; DeAngelis, A; Urbanek, K; Berrino, L; Veltri, P; Paolino, D; Mastroroberto, P; DeFeo, M; Viglietto, G; Weisz, A; Nadal-Ginard, B; Ellison-Hughes, GM; Torella, D Atrial myxomas arise from multipotent cardiac stem cells Journal Article European Heart Journal, pp. 1-16, 2020, ISSN: 0195-668X, (ehaa156). Abstract | Links | BibTeX | Tags: 2020 @article{10.1093/eurheartj/ehaa156, title = {Atrial myxomas arise from multipotent cardiac stem cells}, author = {M Scalise and M Torella and F Marino and M Ravo and G Giurato and C Vicinanza and E Cianflone and T Mancuso and I Aquila and L Salerno and G Nassa and V Agosti and A DeAngelis and K Urbanek and L Berrino and P Veltri and D Paolino and P Mastroroberto and M DeFeo and G Viglietto and A Weisz and B Nadal-Ginard and GM Ellison-Hughes and D Torella}, url = {https://doi.org/10.1093/eurheartj/ehaa156}, doi = {10.1093/eurheartj/ehaa156}, issn = {0195-668X}, year = {2020}, date = {2020-04-24}, journal = {European Heart Journal}, pages = {1-16}, abstract = {Cardiac myxomas usually develop in the atria and consist of an acid-mucopolysaccharide-rich myxoid matrix with polygonal stromal cells scattered throughout. These human benign tumours are a valuable research model because of the rarity of cardiac tumours, their clinical presentation and uncertain origin. Here, we assessed whether multipotent cardiac stem/progenitor cells (CSCs) give rise to atrial myxoma tissue.Twenty-three myxomas were collected and analysed for the presence of multipotent CSCs. We detected myxoma cells positive for c-kit (c-kitpos) but very rare Isl-1 positive cells. Most of the c-kitpos cells were blood lineage-committed CD45pos/CD31pos cells. However, c-kitpos/CD45neg/CD31neg cardiac myxoma cells expressed stemness and cardiac progenitor cell transcription factors. Approximately ≤10% of the c-kitpos/CD45neg/CD31neg myxoma cells also expressed calretinin, a characteristic of myxoma stromal cells. In vitro, the c-kitpos/CD45neg/CD31neg myxoma cells secrete chondroitin-6-sulfate and hyaluronic acid, which are the main components of gelatinous myxoma matrix in vivo. In vitro, c-kitpos/CD45neg/CD31neg myxoma cells have stem cell properties being clonogenic, self-renewing, and sphere forming while exhibiting an abortive cardiac differentiation potential. Myxoma-derived CSCs possess a mRNA and microRNA transcriptome overall similar to normal myocardium-derived c-kitpos/CD45neg/CD31negCSCs , yet showing a relatively small and relevant fraction of dysregulated mRNA/miRNAs (miR-126-3p and miR-335-5p, in particular). Importantly, myxoma-derived CSCs but not normal myocardium-derived CSCs, seed human myxoma tumours in xenograft’s in immunodeficient NOD/SCID mice.Myxoma-derived c-kitpos/CD45neg/CD31neg CSCs fulfill the criteria expected of atrial myxoma-initiating stem cells. The transcriptome of these cells indicates that they belong to or are derived from the same lineage as the atrial multipotent c-kitpos/CD45neg/CD31neg CSCs. Taken together the data presented here suggest that human myxomas could be the first-described CSC-related human heart disease.}, note = {ehaa156}, keywords = {2020}, pubstate = {published}, tppubtype = {article} } Cardiac myxomas usually develop in the atria and consist of an acid-mucopolysaccharide-rich myxoid matrix with polygonal stromal cells scattered throughout. These human benign tumours are a valuable research model because of the rarity of cardiac tumours, their clinical presentation and uncertain origin. Here, we assessed whether multipotent cardiac stem/progenitor cells (CSCs) give rise to atrial myxoma tissue.Twenty-three myxomas were collected and analysed for the presence of multipotent CSCs. We detected myxoma cells positive for c-kit (c-kitpos) but very rare Isl-1 positive cells. Most of the c-kitpos cells were blood lineage-committed CD45pos/CD31pos cells. However, c-kitpos/CD45neg/CD31neg cardiac myxoma cells expressed stemness and cardiac progenitor cell transcription factors. Approximately ≤10% of the c-kitpos/CD45neg/CD31neg myxoma cells also expressed calretinin, a characteristic of myxoma stromal cells. In vitro, the c-kitpos/CD45neg/CD31neg myxoma cells secrete chondroitin-6-sulfate and hyaluronic acid, which are the main components of gelatinous myxoma matrix in vivo. In vitro, c-kitpos/CD45neg/CD31neg myxoma cells have stem cell properties being clonogenic, self-renewing, and sphere forming while exhibiting an abortive cardiac differentiation potential. Myxoma-derived CSCs possess a mRNA and microRNA transcriptome overall similar to normal myocardium-derived c-kitpos/CD45neg/CD31negCSCs , yet showing a relatively small and relevant fraction of dysregulated mRNA/miRNAs (miR-126-3p and miR-335-5p, in particular). Importantly, myxoma-derived CSCs but not normal myocardium-derived CSCs, seed human myxoma tumours in xenograft’s in immunodeficient NOD/SCID mice.Myxoma-derived c-kitpos/CD45neg/CD31neg CSCs fulfill the criteria expected of atrial myxoma-initiating stem cells. The transcriptome of these cells indicates that they belong to or are derived from the same lineage as the atrial multipotent c-kitpos/CD45neg/CD31neg CSCs. Taken together the data presented here suggest that human myxomas could be the first-described CSC-related human heart disease. |
2019 |
Scalise, M; Marino, F; Cianflone, E; Mancuso, T; Marotta, P; Aquila, I; Torella, M; Nadal-Ginard, B; Torella, D Heterogeneity of Adult Cardiac Stem Cells Book Chapter Birbrair, A (Ed.): Stem Cells Heterogeneity in Different Organs, pp. 141-178, Springer International Publishing, Cham, 2019, ISBN: 978-3-030-24108-7. @inbook{scalise2019a, title = {Heterogeneity of Adult Cardiac Stem Cells}, author = {M Scalise and F Marino and E Cianflone and T Mancuso and P Marotta and I Aquila and M Torella and B Nadal-Ginard and D Torella}, editor = {A Birbrair}, doi = {10.1007/978-3-030-24108-7_8}, isbn = {978-3-030-24108-7}, year = {2019}, date = {2019-09-06}, booktitle = {Stem Cells Heterogeneity in Different Organs}, pages = {141-178}, publisher = {Springer International Publishing}, address = {Cham}, series = {Advances in Experimental Medicine and Biology}, keywords = {2019}, pubstate = {published}, tppubtype = {inbook} } |
Marino, F; Scalise, M; Cianflone, E; Mancuso, T; Aquila, I; Agosti, V; Torella, M; Paolino, D; Mollace, V; Nadal-Ginard, B; Torella, D Role of c-Kit in Myocardial Regeneration and Aging Journal Article Frontiers in Endocrinology, 10 (371), 2019, ISSN: 1664-2392. @article{marino2019, title = {Role of c-Kit in Myocardial Regeneration and Aging}, author = {F Marino and M Scalise and E Cianflone and T Mancuso and I Aquila and V Agosti and M Torella and D Paolino and V Mollace and B Nadal-Ginard and D Torella}, editor = {S La Vignera}, url = {https://www.frontiersin.org/article/10.3389/fendo.2019.00371}, doi = {10.3389/fendo.2019.00371}, issn = {1664-2392}, year = {2019}, date = {2019-06-19}, journal = {Frontiers in Endocrinology}, volume = {10}, number = {371}, keywords = {2019}, pubstate = {published}, tppubtype = {article} } |
Aquila, I; Cianflone, E; Scalise, M; Marino, F; Mancuso, T; Filardo, A; Smith, AJ; Cappetta, D; DeAngelis, A; Urbanek, K; Isidori, AM; Torella, M; Agosti, V; Viglietto, G; Nadal-Ginard, B; Hellison-Hughes, GM; Torella, D c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration Journal Article Cell Death & Disease, 10 (436), 2019. @article{Aquila2019, title = {c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration}, author = {I Aquila and E Cianflone and M Scalise and F Marino and T Mancuso and A Filardo and AJ Smith and D Cappetta and A DeAngelis and K Urbanek and AM Isidori and M Torella and V Agosti and G Viglietto and B Nadal-Ginard and GM Hellison-Hughes and D Torella}, doi = {10.1038/s41419-019-1655-5}, year = {2019}, date = {2019-06-04}, journal = {Cell Death & Disease}, volume = {10}, number = {436}, keywords = {2019}, pubstate = {published}, tppubtype = {article} } |
Cianflone, E; Torella, M; Chimenti, C; DeAngelis, A; Beltrami, AP; Urbanek, K; Rota, M; Torella, D Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon? Journal Article Oxidative Medicine and Cellular Longevity, 2019 (5813147), pp. 19, 2019. @article{ecianflone2019, title = {Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon?}, author = {E Cianflone and M Torella and C Chimenti and A DeAngelis and AP Beltrami and K Urbanek and M Rota and D Torella}, editor = {Hindawi}, doi = {10.1155/2019/5813147}, year = {2019}, date = {2019-02-07}, journal = {Oxidative Medicine and Cellular Longevity}, volume = {2019}, number = {5813147}, pages = {19}, keywords = {2019}, pubstate = {published}, tppubtype = {article} } |
2018 |
Torella, D; Iaconetti, C; Tarallo, R; Marino, F; Giurato, G; Veneziano, C; Aquila, I; Scalise, M; Mancuso, T; Cianflone, E; Valeriano, C; Marotta, P; Tammè, L; Vicinanza, C; Sasso, FC; Cozzolino, D; Torella, M; Weisz, A; Indolfi, C MicroRNA Regulation of the Hyper-Proliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes Mellitus Journal Article Diabetes, 67 (10), 2018, ISSN: db171434. @article{torellad2018, title = {MicroRNA Regulation of the Hyper-Proliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes Mellitus}, author = {D Torella and C Iaconetti and R Tarallo and F Marino and G Giurato and C Veneziano and I Aquila and M Scalise and T Mancuso and E Cianflone and C Valeriano and P Marotta and L Tammè and C Vicinanza and FC Sasso and D Cozzolino and M Torella and A Weisz and C Indolfi}, doi = {10.2337/db17-1434}, issn = {db171434}, year = {2018}, date = {2018-09-26}, journal = {Diabetes}, volume = {67}, number = {10}, keywords = {2018}, pubstate = {published}, tppubtype = {article} } |
Carresi, C; Musolino, V; Gliozzi, M; Maiuolo, J; Mollace, R; Nucera, S; Maretta, A; Sergi, D; Muscoli, S; Gratteri, S; Palma, E; Bosco, F; Giancotta, C; Muscoli, C; Marino, F; Aquila, I; Torella, D; Romeo, F; Mollace, V JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 119 , pp. 10-18, 2018, ISSN: 0022-2828. @article{ISI:000435530200002, title = {Anti-oxidant effect of bergamot polyphenolic fraction counteracts doxorubicin-induced cardiomyopathy: Role of autophagy and c-kit(pos)CD45(neg)CD31(neg) cardiac stem cell activation}, author = {C Carresi and V Musolino and M Gliozzi and J Maiuolo and R Mollace and S Nucera and A Maretta and D Sergi and S Muscoli and S Gratteri and E Palma and F Bosco and C Giancotta and C Muscoli and F Marino and I Aquila and D Torella and F Romeo and V Mollace}, doi = {10.1016/j.yjmcc.2018.04.007}, issn = {0022-2828}, year = {2018}, date = {2018-06-01}, journal = {JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY}, volume = {119}, pages = {10-18}, keywords = {2018}, pubstate = {published}, tppubtype = {article} } |
Publications
2020 |
International Journal of Molecular Sciences, 21 (7927), 2020. |
Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease Journal Article Cells, 9 (6), pp. 1558, 2020. |
Unravelling the Biology of Adult Cardiac Stem Cell-Derived Exosomes to Foster Endogenous Cardiac Regeneration and Repair Journal Article Int. J. Mol. Sci., 21 (10), pp. 3725, 2020. |
Atrial myxomas arise from multipotent cardiac stem cells Journal Article European Heart Journal, pp. 1-16, 2020, ISSN: 0195-668X, (ehaa156). |
2019 |
Heterogeneity of Adult Cardiac Stem Cells Book Chapter Birbrair, A (Ed.): Stem Cells Heterogeneity in Different Organs, pp. 141-178, Springer International Publishing, Cham, 2019, ISBN: 978-3-030-24108-7. |
Role of c-Kit in Myocardial Regeneration and Aging Journal Article Frontiers in Endocrinology, 10 (371), 2019, ISSN: 1664-2392. |
c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration Journal Article Cell Death & Disease, 10 (436), 2019. |
Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon? Journal Article Oxidative Medicine and Cellular Longevity, 2019 (5813147), pp. 19, 2019. |
2018 |
MicroRNA Regulation of the Hyper-Proliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes Mellitus Journal Article Diabetes, 67 (10), 2018, ISSN: db171434. |
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 119 , pp. 10-18, 2018, ISSN: 0022-2828. |