Publications

@article{cianfly_2020b,
title = {Statins Stimulate New Myocyte Formation After Myocardial Infarction by Activating Growth and Differentiation of the Endogenous Cardiac Stem Cells},
author = {E Cianflone and D Cappetta and T Mancuso and J Sabatino and F Marino and M Scalise and M Albanese and A Salatino and EI Parrotta and G Cuda and A DeAngelis and L Berrino and F Rossi and B Nadal-Ginard and D Torella and K Urbanek},
editor = {Multidisciplinary Digital Publishing Institute},
url = {https://www.mdpi.com/1422-0067/21/21/7927},
doi = {https://doi.org/10.3390/ijms21217927},
year = {2020},
date = {2020-10-26},
journal = {International Journal of Molecular Sciences},
volume = {21},
number = {7927},
keywords = {2020},
pubstate = {published},
tppubtype = {article}
}

@article{cianflone_2020,
title = {Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease},
author = {E Cianflone and M Torella and F Biamonte and A DeAngelis and K Urbanek and FS Costanzo and M Rota and GM Hellison-Hughes and D Torella},
editor = {Multidisciplinary Digital Publishing Institute},
url = {https://www.mdpi.com/2073-4409/9/6/1558},
doi = {https://doi.org/10.3390/cells9061558},
year = {2020},
date = {2020-06-26},
journal = {Cells},
volume = {9},
number = {6},
pages = {1558},
keywords = {2020},
pubstate = {published},
tppubtype = {article}
}

@article{mancuso2020,
title = {Unravelling the Biology of Adult Cardiac Stem Cell-Derived Exosomes to Foster Endogenous Cardiac Regeneration and Repair},
author = {T Mancuso and A Barone and A Salatino and C Molinaro and F Marino and M Scalise and M Torella and A DeAngelis and K Urbanek and D Torella and E Cianflone},
url = {https://doi.org/10.3390/ijms21103725},
doi = {10.3390/ijms21103725},
year = {2020},
date = {2020-05-25},
journal = {Int. J. Mol. Sci.},
volume = {21},
number = {10},
pages = {3725},
keywords = {2020},
pubstate = {published},
tppubtype = {article}
}

@article{10.1093/eurheartj/ehaa156,
title = {Atrial myxomas arise from multipotent cardiac stem cells},
author = {M Scalise and M Torella and F Marino and M Ravo and G Giurato and C Vicinanza and E Cianflone and T Mancuso and I Aquila and L Salerno and G Nassa and V Agosti and A DeAngelis and K Urbanek and L Berrino and P Veltri and D Paolino and P Mastroroberto and M DeFeo and G Viglietto and A Weisz and B Nadal-Ginard and GM Ellison-Hughes and D Torella},
url = {https://doi.org/10.1093/eurheartj/ehaa156},
doi = {10.1093/eurheartj/ehaa156},
issn = {0195-668X},
year = {2020},
date = {2020-04-24},
journal = {European Heart Journal},
pages = {1-16},
abstract = {Cardiac myxomas usually develop in the atria and consist of an acid-mucopolysaccharide-rich myxoid matrix with polygonal stromal cells scattered throughout. These human benign tumours are a valuable research model because of the rarity of cardiac tumours, their clinical presentation and uncertain origin. Here, we assessed whether multipotent cardiac stem/progenitor cells (CSCs) give rise to atrial myxoma tissue.Twenty-three myxomas were collected and analysed for the presence of multipotent CSCs. We detected myxoma cells positive for c-kit (c-kitpos) but very rare Isl-1 positive cells. Most of the c-kitpos cells were blood lineage-committed CD45pos/CD31pos cells. However, c-kitpos/CD45neg/CD31neg cardiac myxoma cells expressed stemness and cardiac progenitor cell transcription factors. Approximately ≤10% of the c-kitpos/CD45neg/CD31neg myxoma cells also expressed calretinin, a characteristic of myxoma stromal cells. In vitro, the c-kitpos/CD45neg/CD31neg myxoma cells secrete chondroitin-6-sulfate and hyaluronic acid, which are the main components of gelatinous myxoma matrix in vivo. In vitro, c-kitpos/CD45neg/CD31neg myxoma cells have stem cell properties being clonogenic, self-renewing, and sphere forming while exhibiting an abortive cardiac differentiation potential. Myxoma-derived CSCs possess a mRNA and microRNA transcriptome overall similar to normal myocardium-derived c-kitpos/CD45neg/CD31negCSCs , yet showing a relatively small and relevant fraction of dysregulated mRNA/miRNAs (miR-126-3p and miR-335-5p, in particular). Importantly, myxoma-derived CSCs but not normal myocardium-derived CSCs, seed human myxoma tumours in xenograft’s in immunodeficient NOD/SCID mice.Myxoma-derived c-kitpos/CD45neg/CD31neg CSCs fulfill the criteria expected of atrial myxoma-initiating stem cells. The transcriptome of these cells indicates that they belong to or are derived from the same lineage as the atrial multipotent c-kitpos/CD45neg/CD31neg CSCs. Taken together the data presented here suggest that human myxomas could be the first-described CSC-related human heart disease.},
note = {ehaa156},
keywords = {2020},
pubstate = {published},
tppubtype = {article}
}

@article{marino2019,
title = {Role of c-Kit in Myocardial Regeneration and Aging},
author = {F Marino and M Scalise and E Cianflone and T Mancuso and I Aquila and V Agosti and M Torella and D Paolino and V Mollace and B Nadal-Ginard and D Torella},
editor = {S La Vignera},
url = {https://www.frontiersin.org/article/10.3389/fendo.2019.00371},
doi = {10.3389/fendo.2019.00371},
issn = {1664-2392},
year = {2019},
date = {2019-06-19},
journal = {Frontiers in Endocrinology},
volume = {10},
number = {371},
keywords = {2019},
pubstate = {published},
tppubtype = {article}
}

@article{Aquila2019,
title = {c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration},
author = {I Aquila and E Cianflone and M Scalise and F Marino and T Mancuso and A Filardo and AJ Smith and D Cappetta and A DeAngelis and K Urbanek and AM Isidori and M Torella and V Agosti and G Viglietto and B Nadal-Ginard and GM Hellison-Hughes and D Torella},
doi = {10.1038/s41419-019-1655-5},
year = {2019},
date = {2019-06-04},
journal = {Cell Death & Disease},
volume = {10},
number = {436},
keywords = {2019},
pubstate = {published},
tppubtype = {article}
}

@article{ecianflone2019,
title = {Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon?},
author = {E Cianflone and M Torella and C Chimenti and A DeAngelis and AP Beltrami and K Urbanek and M Rota and D Torella},
editor = {Hindawi},
doi = {10.1155/2019/5813147},
year = {2019},
date = {2019-02-07},
journal = {Oxidative Medicine and Cellular Longevity},
volume = {2019},
number = {5813147},
pages = {19},
keywords = {2019},
pubstate = {published},
tppubtype = {article}
}

@article{torellad2018,
title = {MicroRNA Regulation of the Hyper-Proliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes Mellitus},
author = {D Torella and C Iaconetti and R Tarallo and F Marino and G Giurato and C Veneziano and I Aquila and M Scalise and T Mancuso and E Cianflone and C Valeriano and P Marotta and L Tammè and C Vicinanza and FC Sasso and D Cozzolino and M Torella and A Weisz and C Indolfi},
doi = {10.2337/db17-1434},
issn = {db171434},
year = {2018},
date = {2018-09-26},
journal = {Diabetes},
volume = {67},
number = {10},
keywords = {2018},
pubstate = {published},
tppubtype = {article}
}

@article{ISI:000435530200002,
title = {Anti-oxidant effect of bergamot polyphenolic fraction counteracts doxorubicin-induced cardiomyopathy: Role of autophagy and c-kit(pos)CD45(neg)CD31(neg) cardiac stem cell activation},
author = {C Carresi and V Musolino and M Gliozzi and J Maiuolo and R Mollace and S Nucera and A Maretta and D Sergi and S Muscoli and S Gratteri and E Palma and F Bosco and C Giancotta and C Muscoli and F Marino and I Aquila and D Torella and F Romeo and V Mollace},
doi = {10.1016/j.yjmcc.2018.04.007},
issn = {0022-2828},
year = {2018},
date = {2018-06-01},
journal = {JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY},
volume = {119},
pages = {10-18},
keywords = {2018},
pubstate = {published},
tppubtype = {article}
}