Publications

@article{scalise2021,

title = {From Spheroids to Organoids: The Next Generation of Model Systems of Human Cardiac Regeneration in a Dish },

author = {M Scalise and F Marino and L Salerno and E Cianflone and C Molinaro and N Salerno and A DeAngelis and G Viglietto and K Urbanek and D Torella},

editor = {Z Wiener},

doi = {https://doi.org/10.3390/ijms222413180},

year  = {2021},

date = {2021-12-07},

urldate = {2021-12-07},

journal = {Int. J. Mol. Sci.},

volume = {22},

number = {24},

pages = {13180},

keywords = {2021},

pubstate = {published},

tppubtype = {article}

}

@article{cianflone2021a,

title = {Cardiac stem cell therapy towards the clinic: The way forward re-starts from within},

author = {E Cianflone and M Scalise and N Salerno and D Torella},

doi = {10.1016/j.ijcard.2021.10.019},

year  = {2021},

date = {2021-10-20},

journal = {Int J Cardiol},

volume = {S0167-5273(21)01573-4},

keywords = {2021},

pubstate = {published},

tppubtype = {article}

}

@article{scalise2021a,

title = {In vitro CSC-derived cardiomyocytes exhibit the typical microRNA-mRNA blueprint of endogenous cardiomyocytes},

author = {M Scalise and F Marino and L Salerno and T Mancuso and D Cappetta and A Barone and EI Parrotta and A Torella and D Palumbo and P Veltri and A DeAngelis and L Berrino and F Rossi and A Weisz and M Rota and K Urbanek and B Nadal-Ginard and D Torella and E Cianflone},

editor = {N Huang and A Akhtar},

doi = {https://doi.org/10.1038/s42003-021-02677-y},

year  = {2021},

date = {2021-09-30},

urldate = {2021-09-30},

journal = {Communications Biology},

volume = {4},

number = {1146},

keywords = {2021},

pubstate = {published},

tppubtype = {article}

}

@article{pirna_2021,

title = {WIND (Workflow for pIRNAs aNd beyonD): a strategy for in-depth analysis of small RNA-seq data},

author = {K Geles and D Palumbo and A Sellitto and G Giurato and E Cianflone and F Marino and D Torella and V Mirici-Cappa and G Nassa and R Tarallo and A Weisz and F Rizzo},

doi = {10.12688/f1000research.27868.1},

issn = {20461402},

year  = {2021},

date = {2021-07-12},

urldate = {2021-07-12},

journal = {F1000Research},

volume = {10},

number = {1},

keywords = {2021},

pubstate = {published},

tppubtype = {article}

}

@article{marino2021a,

title = {Physical Exercise and Cardiac Repair: The Potential Role of Nitric Oxide in Boosting Stem Cell Regenerative Biology},

author = {F Marino and M Scalise and E Cianflone and L Salerno and D Cappetta and N Salerno and A DeAngelis and D Torella and K Urbanek},

editor = { MC Cerra and S Imbrogno and A Gattuso},

doi = {https://doi.org/10.3390/antiox10071002},

year  = {2021},

date = {2021-06-23},

journal = {Antioxidants},

volume = {10},

number = {7},

pages = {1002},

keywords = {2021},

pubstate = {published},

tppubtype = {article}

}

@article{bernardo2021,

title = {The baby and the bath water: adult cardiac stem cells revisited},

author = {B Nadal-Ginard and E Cianflone and D Torella },

doi = {https://doi.org/10.1093/eurheartj/ehab335},

year  = {2021},

date = {2021-06-21},

journal = {European Heart Journal},

number = {ehab335},

keywords = {2021},

pubstate = {published},

tppubtype = {article}

}

@article{cianfly_2020b,

title = {Statins Stimulate New Myocyte Formation After Myocardial Infarction by Activating Growth and Differentiation of the Endogenous Cardiac Stem Cells},

author = {E Cianflone and D Cappetta and T Mancuso and J Sabatino and F Marino and M Scalise and M Albanese and A Salatino and EI Parrotta and G Cuda and A DeAngelis and L Berrino and F Rossi and B Nadal-Ginard and D Torella and K Urbanek},

editor = {Multidisciplinary Digital Publishing Institute},

url = {https://www.mdpi.com/1422-0067/21/21/7927},

doi = {https://doi.org/10.3390/ijms21217927},

year  = {2020},

date = {2020-10-26},

journal = {International Journal of Molecular Sciences},

volume = {21},

number = {7927},

keywords = {2020},

pubstate = {published},

tppubtype = {article}

}

@article{cianflone_2020,

title = {Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease},

author = {E Cianflone and M Torella and F Biamonte and A DeAngelis and K Urbanek and FS Costanzo and M Rota and GM Hellison-Hughes and D Torella},

editor = {Multidisciplinary Digital Publishing Institute},

url = {https://www.mdpi.com/2073-4409/9/6/1558},

doi = {https://doi.org/10.3390/cells9061558},

year  = {2020},

date = {2020-06-26},

journal = {Cells},

volume = {9},

number = {6},

pages = {1558},

keywords = {2020},

pubstate = {published},

tppubtype = {article}

}

@article{mancuso2020,

title = {Unravelling the Biology of Adult Cardiac Stem Cell-Derived Exosomes to Foster Endogenous Cardiac Regeneration and Repair},

author = {T Mancuso and A Barone and A Salatino and C Molinaro and F Marino and M Scalise and M Torella and A DeAngelis and K Urbanek and D Torella and E Cianflone},

url = {https://doi.org/10.3390/ijms21103725},

doi = {10.3390/ijms21103725},

year  = {2020},

date = {2020-05-25},

journal = {Int. J. Mol. Sci.},

volume = {21},

number = {10},

pages = {3725},

keywords = {2020},

pubstate = {published},

tppubtype = {article}

}

@article{10.1093/eurheartj/ehaa156,

title = {Atrial myxomas arise from multipotent cardiac stem cells},

author = {M Scalise and M Torella and F Marino and M Ravo and G Giurato and C Vicinanza and E Cianflone and T Mancuso and I Aquila and L Salerno and G Nassa and V Agosti and A DeAngelis and K Urbanek and L Berrino and P Veltri and D Paolino and P Mastroroberto and M DeFeo and G Viglietto and A Weisz and B Nadal-Ginard and GM Ellison-Hughes and D Torella},

url = {https://doi.org/10.1093/eurheartj/ehaa156},

doi = {10.1093/eurheartj/ehaa156},

issn = {0195-668X},

year  = {2020},

date = {2020-04-24},

journal = {European Heart Journal},

pages = {1-16},

abstract = {Cardiac myxomas usually develop in the atria and consist of an acid-mucopolysaccharide-rich myxoid matrix with polygonal stromal cells scattered throughout. These human benign tumours are a valuable research model because of the rarity of cardiac tumours, their clinical presentation and uncertain origin. Here, we assessed whether multipotent cardiac stem/progenitor cells (CSCs) give rise to atrial myxoma tissue.Twenty-three myxomas were collected and analysed for the presence of multipotent CSCs. We detected myxoma cells positive for c-kit (c-kitpos) but very rare Isl-1 positive cells. Most of the c-kitpos cells were blood lineage-committed CD45pos/CD31pos cells. However, c-kitpos/CD45neg/CD31neg cardiac myxoma cells expressed stemness and cardiac progenitor cell transcription factors. Approximately ≤10% of the c-kitpos/CD45neg/CD31neg myxoma cells also expressed calretinin, a characteristic of myxoma stromal cells. In vitro, the c-kitpos/CD45neg/CD31neg myxoma cells secrete chondroitin-6-sulfate and hyaluronic acid, which are the main components of gelatinous myxoma matrix in vivo. In vitro, c-kitpos/CD45neg/CD31neg myxoma cells have stem cell properties being clonogenic, self-renewing, and sphere forming while exhibiting an abortive cardiac differentiation potential. Myxoma-derived CSCs possess a mRNA and microRNA transcriptome overall similar to normal myocardium-derived c-kitpos/CD45neg/CD31negCSCs , yet showing a relatively small and relevant fraction of dysregulated mRNA/miRNAs (miR-126-3p and miR-335-5p, in particular). Importantly, myxoma-derived CSCs but not normal myocardium-derived CSCs, seed human myxoma tumours in xenograft’s in immunodeficient NOD/SCID mice.Myxoma-derived c-kitpos/CD45neg/CD31neg CSCs fulfill the criteria expected of atrial myxoma-initiating stem cells. The transcriptome of these cells indicates that they belong to or are derived from the same lineage as the atrial multipotent c-kitpos/CD45neg/CD31neg CSCs. Taken together the data presented here suggest that human myxomas could be the first-described CSC-related human heart disease.},

note = {ehaa156},

keywords = {2020},

pubstate = {published},

tppubtype = {article}

}