In vitro CSC-derived cardiomyocytes exhibit the typical microRNA-mRNA blueprint of endogenous cardiomyocytes. Communications Biology, volume 4, Article number: 1146 |…
Bernardo Nadal-Ginard, Eleonora Cianflone and Daniele Torella European Heart Journal, ehab335, Published: 21 June 2021. Heart failure (HF), the…
The paper received the editorial by Prof. Mark A. Sussman: ‘Atrial Myxoma: the cardiac chameleon’. European Heart Journal, ehaa208.
Abstract. An overdose of Isoproterenol (ISO) causes acute cardiomyocyte (CM) dropout and activates the resident cardiac c-kitpos stem/progenitor cells (CSCs) generating a burst of new CM formation that replaces those lost to ISO. Recently, unsuccessful attempts to reproduce these findings using c-kitCre knock-in (KI) mouse models were reported.
Kitcre knock-in mice fail to fate-map cardiac stem cells Carla Vicinanza, Iolanda Aquila, Eleonora Cianflone, Mariangela Scalise, Fabiola Marino, Teresa…
The epidemic of heart failure has stimulated interest in understanding cardiac regeneration. Evidence has been reported supporting regeneration via transplantation of multiple cell types, as well as replication of postmitotic cardiomyocytes.