104 entries « 1 of 3 »

2023

Scalise, M; Marino, F; Salerno, L; Amato, N; Quercia, C; Siracusa, C; Filardo, A; Chiefalo, A; Pagano, L; Misdea, G; Salerno, N; DeAngelis, A; Urbanek, K; Viglietto, G; Torella, D; Cianflone, E

Adult Multipotent Cardiac Progenitor-Derived Spheroids: A Reproducible Model of In Vitro Cardiomyocyte Commitment and Specification Journal Article

In: Cells, vol. 12, iss. 13, no. 1793, 2023.

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Molinaro, C; Scalise, M; Leo, I; Salerno, L; Sabatino, J; Salerno, N; DeRosa, S; Torella, D; Cianflone, E; Marino, F

Polarizing Macrophage Functional Phenotype to Foster Cardiac Regeneration Journal Article

In: Int. J. Mol. Sci., vol. 24, iss. 13, no. 10747, 2023.

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Salerno, N; Scalise, M; Marino, F; Filardo, A; Chiefalo, A; Panuccio, G; Torella, M; DeAngelis, A; DeRosa, S; Ellison-Hughes, GM; Urbanek, K; Viglietto, G; Torella, D; Cianflone, E

A Mouse Model of Dilated Cardiomyopathy Produced by Isoproterenol Acute Exposure Followed by 5-Fluorouracil Administration Journal Article

In: J. Cardiovasc. Dev. Dis. , vol. 10, iss. 6, no. 225, 2023.

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Torella, D; Salerno, N; Cianflone, E

Senescent cells enhance ischemic aging in the female heart Journal Article

In: Aging (Albany NY), vol. 15, iss. 7, pp. 2364–2366, 2023.

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Marino, F; Salerno, N; Scalise, M; Salerno, L; Torella, A; Molinaro, C; Chiefalo, A; Filardo, A; Siracusa, C; Panuccio, G; Ferravante, C; Giurato, G; Rizzo, F; Torella, M; Donniacuo, M; DeAngelis, A; Viglietto, G; Urbanek, K; Weisz, A; Torella, D; Cianflone, E

Streptozotocin-Induced Type 1 and 2 Diabetes Mellitus Mouse Models Show Different Functional, Cellular and Molecular Patterns of Diabetic Cardiomyopathy Journal Article

In: Int. J. Mol. Sci., vol. 24, iss. 2, no. 1132, 2023.

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2022

Salerno, N; Marino, F; Scalise, M; Salerno, L; Molinaro, C; Filardo, A; Chiefalo, A; Panuccio, G; Angelis, A De; Urbanek, K; Torella, D; Cianflone, E

Pharmacological clearance of senescent cells improves cardiac remodeling and function after myocardial infarction in female aged mice Journal Article

In: vol. 208, no. 111740, 2022, ISSN: 0047-6374.

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Torella, D; Salerno, N; Cianflone, E

SETD7 methyltransferase is a key druggable target for effective cardioprotection from myocardial ischaemic injury  Journal Article

In: Cardiovascular Research, vol. cvac148, 2022, ISSN: 0008-6363, (cvac148).

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Cianflone, E; Scalise, M; Marino, F; Salerno, L; Salerno, N; Urbanek, K; Torella, D

The negative regulation of gene expression by microRNAs as key driver of inducers and repressors of cardiomyocyte differentiation Journal Article

In: Clin Sci (Lond), vol. 136, iss. 16, pp. 1179–1203, 2022.

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Salerno, N; Salerno, L; Marino, F; Scalise, M; Chiefalo, A; Panuccio, G; DeAngelis, A; Cianflone, E; Urbanek, K; Torella, D

Myocardial regeneration protocols towards the routine clinical scenario: An unseemly path from bench to bedside Journal Article

In: eClinicalMedicine, vol. 50, no. 101530, 2022.

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Marino, F; Scalise, M; Salerno, N; Salerno, L; Molinaro, C; Cappetta, D; Torella, M; Greco, M; Foti, D; Sasso, FC; Mastroroberto, P; DeAngelis, A; Ellison-Hughes, GM; Sampaolesi, M; Rota, M; Rossi, F; Urbanek, K; Nadal-Ginard, B; Torella, D; Cianflone, E

Diabetes-Induced Cellular Senescence and Senescence-Associated Secretory Phenotype Impair Cardiac Regeneration and Function Independently of Age Journal Article

In: Diabetes, vol. db210536, 2022.

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Molinaro, C; Salerno, L; Marino, F; Scalise, M; Salerno, N; Pagano, L; DeAngelis, A; Cianflone, E; Torella, D; Urbanek, K

Unraveling and Targeting Myocardial Regeneration Deficit in Diabetes Journal Article

In: Antioxidants, vol. 11, no. 2, pp. 208, 2022.

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2021

Scalise, M; Marino, F; Salerno, L; Cianflone, E; Molinaro, C; Salerno, N; DeAngelis, A; Viglietto, G; Urbanek, K; Torella, D

From Spheroids to Organoids: The Next Generation of Model Systems of Human Cardiac Regeneration in a Dish Journal Article

In: Int. J. Mol. Sci., vol. 22, no. 24, pp. 13180, 2021.

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Cianflone, E; Scalise, M; Salerno, N; Torella, D

Cardiac stem cell therapy towards the clinic: The way forward re-starts from within Journal Article

In: Int J Cardiol, vol. S0167-5273(21)01573-4, 2021.

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Scalise, M; Marino, F; Salerno, L; Mancuso, T; Cappetta, D; Barone, A; Parrotta, EI; Torella, A; Palumbo, D; Veltri, P; DeAngelis, A; Berrino, L; Rossi, F; Weisz, A; Rota, M; Urbanek, K; Nadal-Ginard, B; Torella, D; Cianflone, E

In vitro CSC-derived cardiomyocytes exhibit the typical microRNA-mRNA blueprint of endogenous cardiomyocytes Journal Article

In: Communications Biology, vol. 4, no. 1146, 2021.

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Geles, K; Palumbo, D; Sellitto, A; Giurato, G; Cianflone, E; Marino, F; Torella, D; Mirici-Cappa, V; Nassa, G; Tarallo, R; Weisz, A; Rizzo, F

WIND (Workflow for pIRNAs aNd beyonD): a strategy for in-depth analysis of small RNA-seq data Journal Article

In: F1000Research, vol. 10, no. 1, 2021, ISSN: 20461402.

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Marino, F; Scalise, M; Cianflone, E; Salerno, L; Cappetta, D; Salerno, N; DeAngelis, A; Torella, D; Urbanek, K

Physical Exercise and Cardiac Repair: The Potential Role of Nitric Oxide in Boosting Stem Cell Regenerative Biology Journal Article

In: Antioxidants, vol. 10, no. 7, pp. 1002, 2021.

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Nadal-Ginard, B; Cianflone, E; Torella, D

The baby and the bath water: adult cardiac stem cells revisited Journal Article

In: European Heart Journal, no. ehab335, 2021.

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2020

Cianflone, E; Cappetta, D; Mancuso, T; Sabatino, J; Marino, F; Scalise, M; Albanese, M; Salatino, A; Parrotta, EI; Cuda, G; DeAngelis, A; Berrino, L; Rossi, F; Nadal-Ginard, B; Torella, D; Urbanek, K

Statins Stimulate New Myocyte Formation After Myocardial Infarction by Activating Growth and Differentiation of the Endogenous Cardiac Stem Cells Journal Article

In: International Journal of Molecular Sciences, vol. 21, no. 7927, 2020.

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Cianflone, E; Torella, M; Biamonte, F; DeAngelis, A; Urbanek, K; Costanzo, FS; Rota, M; Hellison-Hughes, GM; Torella, D

Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease Journal Article

In: Cells, vol. 9, no. 6, pp. 1558, 2020.

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Mancuso, T; Barone, A; Salatino, A; Molinaro, C; Marino, F; Scalise, M; Torella, M; DeAngelis, A; Urbanek, K; Torella, D; Cianflone, E

Unravelling the Biology of Adult Cardiac Stem Cell-Derived Exosomes to Foster Endogenous Cardiac Regeneration and Repair Journal Article

In: Int. J. Mol. Sci., vol. 21, no. 10, pp. 3725, 2020.

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Scalise, M; Torella, M; Marino, F; Ravo, M; Giurato, G; Vicinanza, C; Cianflone, E; Mancuso, T; Aquila, I; Salerno, L; Nassa, G; Agosti, V; Angelis, A De; Urbanek, K; Berrino, L; Veltri, P; Paolino, D; Mastroroberto, P; Feo, M De; Viglietto, G; Weisz, A; Nadal-Ginard, B; Ellison-Hughes, GM; Torella, D

Atrial myxomas arise from multipotent cardiac stem cells Journal Article

In: Eur Heart J, vol. 41, iss. 45, pp. 4332-4345, 2020, ISSN: 1522-9645 (Electronic) 0195-668X (Linking).

Links | BibTeX | Tags: 2020

Scalise, M; Torella, M; Marino, F; Ravo, M; Giurato, G; Vicinanza, C; Cianflone, E; Mancuso, T; Aquila, I; Salerno, L; Nassa, G; Agosti, V; DeAngelis, A; Urbanek, K; Berrino, L; Veltri, P; Paolino, D; Mastroroberto, P; DeFeo, M; Viglietto, G; Weisz, A; Nadal-Ginard, B; Ellison-Hughes, GM; Torella, D

Atrial myxomas arise from multipotent cardiac stem cells Journal Article

In: European Heart Journal, pp. 1-16, 2020, ISSN: 0195-668X, (ehaa156).

Abstract | Links | BibTeX | Tags: 2020

2019

Scalise, M; Marino, F; Cianflone, E; Mancuso, T; Marotta, P; Aquila, I; Torella, M; Nadal-Ginard, B; Torella, D

Heterogeneity of Adult Cardiac Stem Cells Book Chapter

In: Birbrair, A (Ed.): Stem Cells Heterogeneity in Different Organs, pp. 141-178, Springer International Publishing, Cham, 2019, ISBN: 978-3-030-24108-7.

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Marino, F; Scalise, M; Cianflone, E; Mancuso, T; Aquila, I; Agosti, V; Torella, M; Paolino, D; Mollace, V; Nadal-Ginard, B; Torella, D

Role of c-Kit in Myocardial Regeneration and Aging Journal Article

In: Frontiers in Endocrinology, vol. 10, no. 371, 2019, ISSN: 1664-2392.

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Aquila, I; Cianflone, E; Scalise, M; Marino, F; Mancuso, T; Filardo, A; Smith, AJ; Cappetta, D; DeAngelis, A; Urbanek, K; Isidori, AM; Torella, M; Agosti, V; Viglietto, G; Nadal-Ginard, B; Hellison-Hughes, GM; Torella, D

c-kit Haploinsufficiency impairs adult cardiac stem cell growth, myogenicity and myocardial regeneration Journal Article

In: Cell Death & Disease, vol. 10, no. 436, 2019.

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Cianflone, E; Torella, M; Chimenti, C; DeAngelis, A; Beltrami, AP; Urbanek, K; Rota, M; Torella, D

Adult Cardiac Stem Cell Aging: A Reversible Stochastic Phenomenon? Journal Article

In: Oxidative Medicine and Cellular Longevity, vol. 2019, no. 5813147, pp. 19, 2019.

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2018

Torella, D; Iaconetti, C; Tarallo, R; Marino, F; Giurato, G; Veneziano, C; Aquila, I; Scalise, M; Mancuso, T; Cianflone, E; Valeriano, C; Marotta, P; Tammè, L; Vicinanza, C; Sasso, FC; Cozzolino, D; Torella, M; Weisz, A; Indolfi, C

MicroRNA Regulation of the Hyper-Proliferative Phenotype of Vascular Smooth Muscle Cells in Diabetes Mellitus Journal Article

In: Diabetes, vol. 67, no. 10, 2018, ISSN: db171434.

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Carresi, C; Musolino, V; Gliozzi, M; Maiuolo, J; Mollace, R; Nucera, S; Maretta, A; Sergi, D; Muscoli, S; Gratteri, S; Palma, E; Bosco, F; Giancotta, C; Muscoli, C; Marino, F; Aquila, I; Torella, D; Romeo, F; Mollace, V

Anti-oxidant effect of bergamot polyphenolic fraction counteracts doxorubicin-induced cardiomyopathy: Role of autophagy and c-kit(pos)CD45(neg)CD31(neg) cardiac stem cell activation Journal Article

In: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 119, pp. 10-18, 2018, ISSN: 0022-2828.

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Vicinanza, C; Aquila, I; Cianflone, E; Scalise, M; Marino, F; Mancuso, T; Fumagalli, F; Giovannone, ED; Cristiano, F; Iaccino, E; Marotta, P; Torella, A; Latini, R; Agosti, V; Veltri, P; Urbanek, K; Isidori, AM; Saur, D; Indolfi, C; Nadal-Ginard, B; Torella, D

Kit(cre) knock-in mice fail to fate-map cardiac stem cells Journal Article

In: NATURE, vol. 555, no. 7697, pp. E1-E17, 2018, ISSN: 0028-0836.

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Cianflone, E; Aquila, I; Scalise, M; Marotta, P; Torella, M; Nadal-Ginard, B; Torella, D

Molecular basis of functional myogenic specification of Bona Fide multipotent adult cardiac stem cells Journal Article

In: CELL CYCLE, vol. 17, no. 8, pp. 927-946, 2018, ISSN: 1538-4101.

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Marotta, P; Cianflone, E; Aquila, I; Vicinanza, C; Scalise, M; Marino, F; Mancuso, T; Torella, M; Indolfi, C; Torella, D

Combining cell and gene therapy to advance cardiac regeneration Journal Article

In: EXPERT OPINION ON BIOLOGICAL THERAPY, vol. 18, no. 4, pp. 409-423, 2018, ISSN: 1471-2598.

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Nadal-Ginard, B; Torella, D; Angelis, A De; Rossi, F

Monographic issue of pharmacological research on adult myocardial repair/regeneration Journal Article

In: PHARMACOLOGICAL RESEARCH, vol. 127, pp. 1-3, 2018, ISSN: 1043-6618.

Links | BibTeX | Tags: 2018

Aquila, I; Marino, F; Cianflone, E; Marotta, P; Torella, M; Mollace, V; Indolfi, C; Nadal-Ginard, B; Torella, D

The use and abuse of Cre/Lox recombination to identify adult cardiomyocyte renewal rate and origin Journal Article

In: PHARMACOLOGICAL RESEARCH, vol. 127, pp. 116-128, 2018, ISSN: 1043-6618.

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2017

Vicinanza, C; Aquila, I; Scalise, M; Cristiano, F; Marino, F; Cianflone, E; Mancuso, T; Marotta, P; Sacco, W; Lewis, FC; Couch, L; Shone, V; Gritti, G; ATorella,; Smith, AJ; Terracciano, CMN; Britti, D; Veltri, P; Indolfi, C; Nadal-Ginard, B; Ellison-Hughes, GM; Torella, D

Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification Journal Article

In: CELL DEATH AND DIFFERENTIATION, vol. 24, no. 12, pp. 2101-2116, 2017, ISSN: 1350-9047.

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2016

Scalise, M; Vicinanza, C; Aquila, I; Marino, F; Cianflone, E; Mancuso, T; Filardo, A; Indolfi, C; Nadal-Ginard, B; Ellison-Hughes, GM; Torella, D

C-kit expression is necessary but not sufficient to identify multipotent and robustly myogenic adult cardiac stem cells Proceedings Article

In: pp. 517, 2016, ISSN: 0195-668X, (Congress of the European-Society-of-Cardiology (ESC), Rome, ITALY, AUG 27-31, 2016).

BibTeX | Tags: 2016

Aquila, I; Vicinanza, C; Scalise, M; Marino, F; Cianflone, E; Mancuso, T; Filardo, A; Indolfi, C; Nadal-Ginard, B; Torella, D

c-kit/CreERT2 knock-in allele does not efficiently fate-track c-kit positive resident cardiac stem cells and impairs their regenerative potential Proceedings Article

In: pp. 835, 2016, ISSN: 0195-668X, (Congress of the European-Society-of-Cardiology (ESC), Rome, ITALY, AUG 27-31, 2016).

BibTeX | Tags: 2016

Cianflone, E; Marino, F; Scalise, M; Aquila, I; Vicinanza, C; Mancuso, T; Filardo, A; Garcia-Ramirez, I; Indolfi, C; Garcia, I Sanchez; Torella, D

The heart has a constant and significant cardiomyocyte replacement rate by endogenous cardiac stem cells in the adult life Proceedings Article

In: pp. 835, 2016, ISSN: 0195-668X, (Congress of the European-Society-of-Cardiology (ESC), Rome, ITALY, AUG 27-31, 2016).

BibTeX | Tags: 2016

Marino, F; Aquila, I; Mancuso, T; Cianflone, E; Scalise, M; Vicinanza, C; Filardo, A; Mollace, V; Indolfi, C; Nadal-Ginard, B; Torella, D

Selective loss of adult cardiomyocytes is replenished by new endogenous cardiomyocyte formation in the presence of a patent coronary circulation Proceedings Article

In: pp. 835-836, 2016, ISSN: 0195-668X, (Congress of the European-Society-of-Cardiology (ESC), Rome, ITALY, AUG 27-31, 2016).

BibTeX | Tags: 2016

Siena, S Di; Gimmelli, R; Nori, S L; Barbagallo, F; Campolo, F; Dolci, S; Rossi, P; Venneri, M A; Giannetta, E; Gianfrilli, D; Feigenbaum, L; Lenzi, A; Naro, F; Cianflone, E; Mancuso, T; Torella, D; Isidori, A M; Pellegrini, M

Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury Journal Article

In: CELL DEATH & DISEASE, vol. 7, 2016, ISSN: 2041-4889.

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2015

Cianflone, E; Vicinanza, C; Aquila, I; Scalise, M; Marino, F; Mancuso, T; Giovannone, ED; Indolfi, C; Ellison, GM; Nadal-Ginard, B; Torella, D

C-kit/Creert2 knock-in allele minimally tags c-kit positive resident endogenous cardiac stem cells and its cardiomyocyte progeny in the adult life Proceedings Article

In: pp. 45, 2015, ISSN: 1537-1891.

Links | BibTeX | Tags: 2015

Marino, F; Aquila, I; Carresi, C; Mancuso, T; Cianflone, E; Mollace, V; Indolfi, C; Ellison, GM; Nadal-Ginard, B; Torella, D

The adult myocardium has a robust endogenous cardiomyocyte turnover potential Proceedings Article

In: pp. 60-61, 2015, ISSN: 1537-1891.

Links | BibTeX | Tags: 2015

Scalise, M; Aquila, I; Vicinanza, C; Marino, F; Cristiano, F; Cianflone, E; Veltri, P; Indolfi, C; Nadal-Ginard, B; Ellison, GM; Torella, D

C-kit plus CSC-derived cardiomyocytes exhibit the typical transcriptional gene blueprint of adult cardiomyocytes Journal Article

In: VASCULAR PHARMACOLOGY, vol. 75, pp. 69, 2015, ISSN: 1537-1891.

Links | BibTeX | Tags: 2015

Smith, AJ; Aquila, I; Henning, BJ; Scalise, M; Nadal-Ginard, B; Ellison, GM; Torella, D

Endogenous Cardiac Stem Cells' Activation in Response to Injury Potentiates Their Regenerative Ability Proceedings Article

In: 2015, ISSN: 0009-7322, (Scientific Sessions and Resuscitation Science Symposium of the American-Heart-Association (AHA), Orlando, FL, NOV 07-11, 2015).

BibTeX | Tags: 2015

Marino, F; Aquila, I; Mancuso, T; Cianflone, E; Carresi, C; Mollace, V; Indolfi, C; Ellison, GM; Nadal-Ginard, B; Torella, D

The adult myocardium has a robust endogenous cardiomyocyte turnover potential Proceedings Article

In: pp. 611-612, 2015, ISSN: 0195-668X, (Congress of the European-Society-of-Cardiology (ESC), London, ENGLAND, AUG 29-SEP 02, 2015).

BibTeX | Tags: 2015

Cianflone, E; Vicinanza, C; Aquila, I; Scalise, M; Marino, F; Mancuso, T; Giovannone, ED; Ellison, GM; Nadal-Ginard, B; Torella, D

c-kit/CreERT2 knock-in allele minimally tags c-kit positive resident endogenous cardiac stem cells and its cardiomyocyte progeny in the adult life Proceedings Article

In: pp. 612, 2015, ISSN: 0195-668X, (Congress of the European-Society-of-Cardiology (ESC), London, ENGLAND, AUG 29-SEP 02, 2015).

BibTeX | Tags: 2015

Smith, AJ; Aquila, I; Marino, F; Scalise, M; Henning, BJ; Nadal-Ginard, B; Ellison, GM; Torella, D

In situ activation of endogenous cardiac stem cells alters their secretome, miRnome, potentiating their regenerative capacity on the injured heart Proceedings Article

In: pp. 612-613, 2015, ISSN: 0195-668X, (Congress of the European-Society-of-Cardiology (ESC), London, ENGLAND, AUG 29-SEP 02, 2015).

BibTeX | Tags: 2015

Scalise, M; Aquila, I; Vicinanza, C; Marino, F; Cristiano, F; Cianflone, E; Veltri, P; Nadal-Ginard, B; Ellison, GM; Torella, D

c-kit plus CSC-derived cardiomyocytes exhibit the typical transcriptional gene blueprint of adult cardiomyocytes Proceedings Article

In: pp. 950, 2015, ISSN: 0195-668X, (Congress of the European-Society-of-Cardiology (ESC), London, ENGLAND, AUG 29-SEP 02, 2015).

BibTeX | Tags: 2015

Torella, D; Indolfi, C; Nadal-Ginard, B

Generation of new cardiomyocytes after injury: de novo formation from resident progenitors vs. replication of pre-existing cardiomyocytes Journal Article

In: ANNALS OF TRANSLATIONAL MEDICINE, vol. 3, no. 1, 2015, ISSN: 2305-5839.

Links | BibTeX | Tags: 2015

Theologou, T; Field, M; Oo, A; Kuduvalli, M; Casal, M P; Waring, C; Ellison, GM; Torella, D; Nadal-Ginard, B

Transcriptional profile of c-kit positive cardiac stem-progenitor cells (c-kitpos eCSCs) isolated from the four chambers of the adult human heart Proceedings Article

In: pp. 31, 2015, ISSN: 0007-1323, (Annual Meeting of the Society-of-Academic-and-Research-Surgery (SARS(, Durham Univ, Durham, ENGLAND, JAN 07-08, 2015).

BibTeX | Tags: 2015

2014

Nadal-Ginard, B; Ellison, GM; Torella, D

Response to Molkentin's Letter to The Editor Regarding Article, ``The Absence of Evidence Is Not Evidence of Absence: The Pitfalls of Cre Knock-Ins in the c-kit Locus'' Journal Article

In: CIRCULATION RESEARCH, vol. 115, no. 12, pp. E38-E39, 2014, ISSN: 0009-7330.

Links | BibTeX | Tags: 2014

104 entries « 1 of 3 »