2020
Cianflone, E; Cappetta, D; Mancuso, T; Sabatino, J; Marino, F; Scalise, M; Albanese, M; Salatino, A; Parrotta, EI; Cuda, G; DeAngelis, A; Berrino, L; Rossi, F; Nadal-Ginard, B; Torella, D; Urbanek, K
In: International Journal of Molecular Sciences, vol. 21, no. 7927, 2020.
@article{cianfly_2020b,
title = {Statins Stimulate New Myocyte Formation After Myocardial Infarction by Activating Growth and Differentiation of the Endogenous Cardiac Stem Cells},
author = {E Cianflone and D Cappetta and T Mancuso and J Sabatino and F Marino and M Scalise and M Albanese and A Salatino and EI Parrotta and G Cuda and A DeAngelis and L Berrino and F Rossi and B Nadal-Ginard and D Torella and K Urbanek},
editor = {Multidisciplinary Digital Publishing Institute},
url = {https://www.mdpi.com/1422-0067/21/21/7927},
doi = {https://doi.org/10.3390/ijms21217927},
year = {2020},
date = {2020-10-26},
journal = {International Journal of Molecular Sciences},
volume = {21},
number = {7927},
keywords = {2020},
pubstate = {published},
tppubtype = {article}
}
Cianflone, E; Torella, M; Biamonte, F; DeAngelis, A; Urbanek, K; Costanzo, FS; Rota, M; Hellison-Hughes, GM; Torella, D
Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease Journal Article
In: Cells, vol. 9, no. 6, pp. 1558, 2020.
@article{cianflone_2020,
title = {Targeting Cardiac Stem Cell Senescence to Treat Cardiac Aging and Disease},
author = {E Cianflone and M Torella and F Biamonte and A DeAngelis and K Urbanek and FS Costanzo and M Rota and GM Hellison-Hughes and D Torella},
editor = {Multidisciplinary Digital Publishing Institute},
url = {https://www.mdpi.com/2073-4409/9/6/1558},
doi = {https://doi.org/10.3390/cells9061558},
year = {2020},
date = {2020-06-26},
journal = {Cells},
volume = {9},
number = {6},
pages = {1558},
keywords = {2020},
pubstate = {published},
tppubtype = {article}
}
Mancuso, T; Barone, A; Salatino, A; Molinaro, C; Marino, F; Scalise, M; Torella, M; DeAngelis, A; Urbanek, K; Torella, D; Cianflone, E
Unravelling the Biology of Adult Cardiac Stem Cell-Derived Exosomes to Foster Endogenous Cardiac Regeneration and Repair Journal Article
In: Int. J. Mol. Sci., vol. 21, no. 10, pp. 3725, 2020.
@article{mancuso2020,
title = {Unravelling the Biology of Adult Cardiac Stem Cell-Derived Exosomes to Foster Endogenous Cardiac Regeneration and Repair},
author = {T Mancuso and A Barone and A Salatino and C Molinaro and F Marino and M Scalise and M Torella and A DeAngelis and K Urbanek and D Torella and E Cianflone},
url = {https://doi.org/10.3390/ijms21103725},
doi = {10.3390/ijms21103725},
year = {2020},
date = {2020-05-25},
journal = {Int. J. Mol. Sci.},
volume = {21},
number = {10},
pages = {3725},
keywords = {2020},
pubstate = {published},
tppubtype = {article}
}
Scalise, M; Torella, M; Marino, F; Ravo, M; Giurato, G; Vicinanza, C; Cianflone, E; Mancuso, T; Aquila, I; Salerno, L; Nassa, G; Agosti, V; Angelis, A De; Urbanek, K; Berrino, L; Veltri, P; Paolino, D; Mastroroberto, P; Feo, M De; Viglietto, G; Weisz, A; Nadal-Ginard, B; Ellison-Hughes, GM; Torella, D
Atrial myxomas arise from multipotent cardiac stem cells Journal Article
In: Eur Heart J, vol. 41, iss. 45, pp. 4332-4345, 2020, ISSN: 1522-9645 (Electronic) 0195-668X (Linking).
@article{scalise2020,
title = {Atrial myxomas arise from multipotent cardiac stem cells},
author = {M Scalise and M Torella and F Marino and M Ravo and G Giurato and C Vicinanza and E Cianflone and T Mancuso and I Aquila and L Salerno and G Nassa and V Agosti and A De Angelis and K Urbanek and L
Berrino and P Veltri and D Paolino and P Mastroroberto and M De Feo and G Viglietto and A Weisz and B Nadal-Ginard and GM Ellison-Hughes and D Torella},
url = {https://academic.oup.com/eurheartj/article/41/45/4332/5824913},
doi = {10.1093/eurheartj/ehaa156},
issn = {1522-9645 (Electronic) 0195-668X (Linking)},
year = {2020},
date = {2020-04-25},
journal = {Eur Heart J},
volume = {41},
issue = {45},
pages = {4332-4345},
keywords = {2020},
pubstate = {published},
tppubtype = {article}
}
Scalise, M; Torella, M; Marino, F; Ravo, M; Giurato, G; Vicinanza, C; Cianflone, E; Mancuso, T; Aquila, I; Salerno, L; Nassa, G; Agosti, V; DeAngelis, A; Urbanek, K; Berrino, L; Veltri, P; Paolino, D; Mastroroberto, P; DeFeo, M; Viglietto, G; Weisz, A; Nadal-Ginard, B; Ellison-Hughes, GM; Torella, D
Atrial myxomas arise from multipotent cardiac stem cells Journal Article
In: European Heart Journal, pp. 1-16, 2020, ISSN: 0195-668X, (ehaa156).
Abstract | Links | BibTeX | Tags: 2020
@article{10.1093/eurheartj/ehaa156,
title = {Atrial myxomas arise from multipotent cardiac stem cells},
author = {M Scalise and M Torella and F Marino and M Ravo and G Giurato and C Vicinanza and E Cianflone and T Mancuso and I Aquila and L Salerno and G Nassa and V Agosti and A DeAngelis and K Urbanek and L Berrino and P Veltri and D Paolino and P Mastroroberto and M DeFeo and G Viglietto and A Weisz and B Nadal-Ginard and GM Ellison-Hughes and D Torella},
url = {https://doi.org/10.1093/eurheartj/ehaa156},
doi = {10.1093/eurheartj/ehaa156},
issn = {0195-668X},
year = {2020},
date = {2020-04-24},
journal = {European Heart Journal},
pages = {1-16},
abstract = {Cardiac myxomas usually develop in the atria and consist of an acid-mucopolysaccharide-rich myxoid matrix with polygonal stromal cells scattered throughout. These human benign tumours are a valuable research model because of the rarity of cardiac tumours, their clinical presentation and uncertain origin. Here, we assessed whether multipotent cardiac stem/progenitor cells (CSCs) give rise to atrial myxoma tissue.Twenty-three myxomas were collected and analysed for the presence of multipotent CSCs. We detected myxoma cells positive for c-kit (c-kitpos) but very rare Isl-1 positive cells. Most of the c-kitpos cells were blood lineage-committed CD45pos/CD31pos cells. However, c-kitpos/CD45neg/CD31neg cardiac myxoma cells expressed stemness and cardiac progenitor cell transcription factors. Approximately ≤10% of the c-kitpos/CD45neg/CD31neg myxoma cells also expressed calretinin, a characteristic of myxoma stromal cells. In vitro, the c-kitpos/CD45neg/CD31neg myxoma cells secrete chondroitin-6-sulfate and hyaluronic acid, which are the main components of gelatinous myxoma matrix in vivo. In vitro, c-kitpos/CD45neg/CD31neg myxoma cells have stem cell properties being clonogenic, self-renewing, and sphere forming while exhibiting an abortive cardiac differentiation potential. Myxoma-derived CSCs possess a mRNA and microRNA transcriptome overall similar to normal myocardium-derived c-kitpos/CD45neg/CD31negCSCs , yet showing a relatively small and relevant fraction of dysregulated mRNA/miRNAs (miR-126-3p and miR-335-5p, in particular). Importantly, myxoma-derived CSCs but not normal myocardium-derived CSCs, seed human myxoma tumours in xenograft’s in immunodeficient NOD/SCID mice.Myxoma-derived c-kitpos/CD45neg/CD31neg CSCs fulfill the criteria expected of atrial myxoma-initiating stem cells. The transcriptome of these cells indicates that they belong to or are derived from the same lineage as the atrial multipotent c-kitpos/CD45neg/CD31neg CSCs. Taken together the data presented here suggest that human myxomas could be the first-described CSC-related human heart disease.},
note = {ehaa156},
keywords = {2020},
pubstate = {published},
tppubtype = {article}
}